PowerPoint Presentation
The Road from Biology to Engineering
Outline
Two Directions in Nanotechnology
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DNA: Amazing Nanoscale Building Blocks
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Tool Kits
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METHOD: Nearest Neighbor Model
Theoretical calculation and computer simulation of Y
Display output for pVAX1 Y-DNA
“MOLBEL” Y-DNA Results
Automatic Design of Novel Y-DNA
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Dendrimer-Like DNA Synthesis Strategy
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Denaturing of DL-DNA
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What can you do with “nucleic acid engineered materials”? 1. Gene Delivery 2. Nanotechnology
Gene therapy and Non-viral DNA Delivery Systems: Major barriers, challenges
Non-viral transfection efficiency
DNA Delivery Pathways and Barriers
Size Distribution and Morphology
Increase Physical Concentration of DNA at the Cell Surface
A silica-based 3-component transfection system
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Transfection by PEG-PAMAM Dendrimer
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Applications of DL-DNA: Multidrug delivery (a plug-n-play modular drug delivery system)
Strategy of “learning from viruses”
Multiple Drug Delivery
Plug-and-play Multi-gene/drug Delivery System
Applications of DL-DNA: Nanotechnology (DNA barcode, DNA template and DNA nanopatterns)
Decoding by differences in color intensities
Decoding by differences in color patterns
Allergic response pathways (multivalent template)
Degranulation via bi-valent DNP-dsDNA ligands
Use multi-valent DNP-dsDNA ligands to study the mechanistic details of the pathway
DNA nanopatterns and nanowire: nanoscale electronics?
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Conclusion
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Biological Engineering as a discipline
Theoretical Calculation of joint penalties
Author: Clarkson University